Trazodone max dose for sleep. 50 mg tablets; 100 mg tablets; .
Trazodone max dose for sleep I think the max dose is 400 so I still have a lot of room. Adverse effects May 17, 2021 · The dosage for trazodone for insomnia can range between 500mg and 400mg taken once or twice a day, however, the typical dosage is usually between 25mg and 150mg taken 30-minutes before bed. Hence, trazodone maximum dose for sleep is 100 mg. For anxiety, the usual dose is 75mg daily. Insomnia: Studies showed that administering 50 to 100 mg per day of trazodone helped nonorganic insomnia due to depressive disorder, with 100 mg dosage as the most effective to improve sleep. When used to help people sleep, the dosage of trazodone prescribed differs from other use cases. telling you so. The maximum dose of trazodone used for outpatients is 400 None seem to be able to give me more sleep than a few hours per night- i have not tried high dosage of cbd. I’m curious if i should start trying at 25 mg or 50 mg trazodone to bypass grogginess or fatigue. The dosage is typically determined by a healthcare professional and may need to be adjusted based on individual response and tolerance. The dosage should be initiated at a low-dose and increased gradually, noting the clinical response and any evidence of intolerance. The dose of extended-release tablets is 150 mg at bedtime initially which is increased by 75 mg/day every 3 days. It helped put me to sleep, but I’d wake up about 4 hours later. An initial dose of 150 mg/day in divided doses is suggested. Aug 1, 2017 · Earlier studies (1980-2000) focused on utilizing trazodone at high doses (≥100mg/d) for the treatment of insomnia among the depressed population; however, since the 2000s, the utility of trazodone has been expanded to treat secondary insomnia among the non-depressed population as well. Trazodone 150 mg before bedtime. Nov 25, 2024 · The effect of short-term administration of ritonavir (200 mg twice daily, 4 doses) on the pharmacokinetics of a single dose of trazodone (50 mg) has been studied in 10 healthy subjects. , more severely depressed patients) may be given up to but not in excess of 600 mg/day in divided doses. Trazodone is a prescription oral selective serotonin reuptake inhibitor used for treatment of major depressive disorder and other conditions including anxiety and sleep disorders. Do not chew or crush slow-release tablets. The maximum dose of trazodone for sleep may vary depending on individual factors such as age, weight, and overall health condition. Occurrence of drowsiness may require the administration of a major portion of the daily dose at bedtime or a reduction of dosage. My doctor said that if over 300 mg doesn’t work, then it’s not really effective for the person. Adverse effects It is very effective in the treatment of depression, in anxiety and insomnia. Maximum dose: 400 mg per day in divided doses ( 2). It’s crucial to adhere to the prescribed dosage and not exceed the recommended amount without consulting a healthcare provider. Trazodone (brand names Desyrel, Molipaxin, Deprax, Trittico, Thombran, Trialodine, Trazorel) is a psychoactive compound with sedative, anxiolytic, and antidepressant properties. Oct 10, 2024 · Serious side effects of trazodone. I've been trying to function on 3 or 4 hours sleep. A review of trazodone use in psychiatric and medical conditions. Hospitalized Patients Oral Maximum 600 mg daily. Now, it doesn’t do anything, even at a double dose. 16 votes, 85 comments. A 2023 review found that 50 mg of trazodone taken before bed may help you: fall asleep quicker Nov 1, 2024 · The typical trazodone dosage for sleep is 25 mg to 100 mg before bedtime. Although not all of these side effects may occur, if they do occur they may need medical attention. Sleep Wake Advisor; The Cardiology Advisor May increase by 50mg/day at 3–4 day intervals; max Jan 11, 2020 · Doses predicted in the following age groups, with exposures corresponding to adult dosages of 30 mg, 75 mg and 150 mg once-a-day (QD) respectively were: 2-6 yr old group: doses of 0. Jun 2, 2022 · Older adults typically use a lower dosage of trazodone. Jun 17, 2021 · Trazodone is prescribed at doses between 50-150 mg when prescribed as a sleep aid. C max value increases by 86% when the drug is administered with food 28. Significant improvements from baseline in HAM-D scores were also seen with trazodone IR (dose range 50–400 mg/day) and fluoxetine (dose range 20–40 mg/day) in a larger randomized, double-blind study (n = 126) of outpatients with MDD—these improvements in clinical efficacy were similar between the two treatment groups, but HAM-D sleep portion of the daily dose at bedtime or a reduction of dosage. Oct 7, 2022 · For the treatment of depression, a normal starting dose is 150 milligrams (mg) per day. Max: 150 mg/day. The maximum dose is 400 mg per day in divided daily doses. Along with its needed effects, trazodone may cause some unwanted effects. But in some cases your doctor may start you on a lower dose of 100mg to reduce the chance of side effects. Trazodone hydrochloride tablets should be taken shortly after a meal or light snack. I tried trazodone 100mg + zopiclone 7. A low-dose sublingual tablet (1. It may not seem like a big deal, but I haven't done that in years. placebo; other Oct 6, 2017 · dh1968; masso has a great answer, And I have experienced the higher dose and it did not work as well. DOSAGES GENERAL RECOMMENDATIONS. A common side effect of taking trazodone is feeling sleepy or tired. 3 This side effect is what highlighted the potential for trazodone to be used as a sleep aid. In this low-dose range, trazodone is thought to help encourage sleep while limiting the risk of daytime sleepiness. The maximum dose for outpatients usually should not exceed 400 mg/day in divided doses. Understanding the appropriate dosage is essential for both the efficacy and safety of this medication. It must be used The drug has been shown to cause increased fetal resorption and other adverse effects on fetuses in rats when given at dose levels of approximately 7. I’m on 150 mg and it took getting up to this much before I could sleep through the night. People with insomnia usually also take a lower trazodone dose — often between 50 mg and 100 mg. When using trazodone for sleep disorders, the maximum dosage can vary depending on various factors. 41, 42, 44 – 48, 50 In an open-label, six-week RCT, the effective dose of trazodone was evaluated in 75 subjects, with a 50mg/d trazodone dose May 17, 2012 · Maximum dose: 400 mg orally per day in divided doses (outpatients); 600 mg orally per day in divided doses (inpatients) Extended-release tablets: 150 mg orally once a day; this may be increased by 75 mg orally per day every 3 days (i. For oral dosage form (tablets): Adults—At first, 150 milligrams (mg) per day, given in divided doses. You can increase its effect by adding a little mg of melatonin. e. According to EMA guidelines, the initial dose of trazodone should range from 75 to 100 mg/day, administered in a single dose before bedtime. Aug 26, 2024 · The maximum recommended dose of trazodone for sleep is generally considered to be 100 mg. The dose may be increased by 50 mg/day every 3 to 4 days. 2 fold, and the clearance decreased by 52%. Sep 21, 2023 · When taking trazodone, it is important to follow the prescribed dosage and instructions provided by your healthcare provider. Adults—At first, 150 milligrams (mg) per day as a single dose. Now I'm starting to feel like my old self again. Regarding Ambien, please stay far away as possible from this drug. Prescribing Limits Adults Major Depressive Disorder Outpatients Oral Maximum 400 mg daily. I've seen others say they use a significantly higher dose to help with insomnia but the 25mg to 150mg range seems to be fairly common. Exceeding this limit is not recommended without close medical supervision, as higher doses are more suitable for managing depression rather than insomnia. Higher doses of Seroquel are associated with a higher risk of side effects, but even lower doses have been associated with side effects such as Feb 29, 2024 · Insomnia: Studies showed that administering 50 to 100 mg per day of trazodone helped nonorganic insomnia due to depressive disorder, with 100 mg dosage as the most effective to improve sleep. 3 to 11 times the maximum recommended human dose (MRHD) of 400 mg/day in adults on a mg/m2 basis. Apart from that it was Study with Quizlet and memorize flashcards containing terms like Where is trazodone absorbed?, Trazodone therapeutic indications, Trazodone effects on sleep and more. Last night I took a whole pill before I went to sleep and I fell asleep reading. Your doctor may start you on a low dose of trazodone and gradually increase your dose, not more than once every 3 to 4 days. Trazodone is an oral tablet that you typically take in divided doses. Check with your doctor immediately if any of the following side effects occur while taking trazodone: More common side effects The liquid has either 10mg or 20mg of trazodone in every 1ml. Trazodone (50 mg) or placebo was administered 30 minutes before bedtime for 1 week with a 1-week washout between treatment Trazodone is used off label for insomnia as it is primarily an antidepressant. In some cases, users may take more than 100 minutes before dozing off. Don’t increase your dose or stop taking trazodone without first talking to your healthcare Trazodone Dosage. 2-fold, and the clearance decreased by 52%. 35, 0. The maximum daily dose for outpatients is 400 mg/day in Sep 2, 2023 · The prolonged-release trazodone group had received a mean maximum trazodone dosage of 273 mg/day, and had a significantly greater improvement from baseline in mean HAM-D-17 total score at study end (primary outcome) compared to placebo (− 11. It caused disorientation and confusion after using it nightly for a week. , start 225 mg orally on Day 4 of therapy) Maximum dose: 375 mg orally per day Medscape - Depression, Insomnia-specific dosing for Oleptro, Trazodone D (trazodone), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. good luck to you and have a good weekend. Jan 2, 2025 · The recommended trazodone dosage for major depressive disorder (MDD) is between 150 milligrams (mg) and 400 mg. [6] In Italy, it is also available as an oral solution (Trittico 60 mg/mL) with a dosing pipette marked at 25 mg and 50 mg. Trazodone regular tablets are given in one or more daily doses, sometimes with the largest dose at night. Adverse effects 25 to 50 mg PO once daily at bedtime, initially. g. 29, p < 0. many times with Trazodone if you have to go to higher doses it's best the doctor tries something else. 2017;14(7-8):24-34. Minimum dose of trazodone Jun 6, 2024 · How is trazodone supplied (dosage forms)? Trazodone is available in the following dosage forms that are taken by mouth. Learn how to use trazodone for depression, the maximum dose, and the dose adjustments for renal, liver, and dialysis issues. The C max of trazodone increased by 34%, the AUC increased 2. Beyond this dosage, the sedating effects may become more pronounced, increasing the risk of side effects and potentially compromising overall health. A 2018 meta-analysis examining the use of trazodone for insomnia included seven RCTs with 429 adults (mean age = 46. Mar 31, 2021 · The oral bioavailability of trazodone is mostly affected by food. 4 fold, the half-life increased by 2. Oct 25, 2007 · The effect of short-term administration of ritonavir (200 mg twice daily, 4 doses) on the pharmacokinetics of a single dose of trazodone (50 mg) has been studied in 10 healthy subjects. May be increased by 50 mg per day every three to four days. The Prescribing Information insert lists a maximum dose of 400mg or 600mg when used to treat it's approved indication of MDD. Increase the dose as needed and tolerated. Treatment of Depression. Of the total drug interactions, 137 are major, 501 are moderate, and 15 are minor. It takes me 15 to 20 minutes to sleep. Your doctor may adjust your dose as needed. It is able to be used as an off label hypnotic without having antidepressant effects and side effects because its pharmacology is such that at lower doses it is not strong enough to have significant impact on the typical receptor sites associated with depression, while still strong enough to effect sleep-inducing My doctor prescribed Trazodone 50 mg at bedtime. Like I was put in a coma instead of restful sleep. − 8. [50-100 mg PO bid-tid] Start: 25-50 mg PO bid-tid, may incr. Nov 6, 2024 · Jaffer KY, Chang T, Vanle B, et al. Innov Clin Neurosci. Howver, you have to have at least 7 hours of sleep to avoid side efdects in the morning. 8 and 1. There are 653 drugs known to interact with trazodone, along with 8 disease interactions, and 1 alcohol/food interaction. Nov 8, 2024 · Trazodone is most often prescribed at doses between 50 milligrams (mg) to 100 mg as a sleep aid. 3. Common trazodone brands names include Desyrel and Desyrel Dividose. . Trazodone hydrochloride tablets should be taken shortly after a meal or light snack ( 2). Nov 29, 2024 · The typical starting trazodone dosage is 25-50 mg, which may be adjusted based on your response. Trazodone is provided as the hydrochloride salt and is available in the form of 50 mg, 100 mg, 150 mg, and 300 mg oral tablets. Venlafaxine 37. Trazodone is generally considered safe to use short-term for sleep issues. Zolpidem 5 mg before bedtime. 3 to 22 Initially 150 mg daily in divided doses, dose to be taken after food, alternatively initially 150 mg once daily, dose to be taken at bedtime, increased if necessary to 300 mg daily; increased if necessary to 600 mg daily in divided doses, higher dose for use in hospital patients only. Key Takeaways: Quick Answers About Trazodone for Aug 7, 2024 · The effect of short-term administration of ritonavir (200 mg twice daily, 4 doses) on the pharmacokinetics of a single dose of trazodone (50 mg) has been studied in 10 healthy subjects. Several factors can influence the maximum dose of Aug 22, 2023 · For immediate-release zolpidem formulations, the starting dose is 5 mg in females and 5 to 10 mg in males; a higher dose (10 mg) can be used in younger adults, but the maximum recommended dose is 5 mg for older adults. Mar 14, 2024 · The maximum recommended dose for depression is 400 mg per day. This guide provides detailed insights and a weight-based dosage chart to ensure your dog receives the optimal amount of Trazodone. I’ve been on trazodone (at a low dose) since the beginning of this year. Trazodone for sleep. May 25, 2012 · Do not adjust your dose or discontinue the medication without consulting your healthcare provider. Trazodone may be available as immediate-release (IR) tablets and, in some countries, prolonged-release tablets, oral drops, and injection solutions. Its known side effects mainly occur with prolonged use of daily doses of 150–200 mg. Oct 20, 2023 · A typical starting dose of trazodone for treating major depressive disorder (MDD) is 150 mg daily divided into 2 to 3 separate doses. Doses higher than this are more commonly associated with its use as an antidepressant rather than a sleep aid. Inpatients (i. When the regular tablets are taken, this would most likely be scheduled as 75 mg in the morning and 75 mg at night. For the treatment of insomnia, the dose is usually started with 25 to 50 mg at night. Trazodone hydrochloride tablets should be taken shortly after a meal or light snack . Though, some studies suggest that a lower dosage may prevent daytime lethargy (sleepiness) and reduce the risk of unpleasant side-effects (i. 1 years; range = 38. Mar 5, 2024 · The effect of short-term administration of ritonavir (200 mg twice daily, 4 doses) on the pharmacokinetics of a single dose of trazodone (50 mg) has been studied in 10 healthy subjects. Selection of a medication that addresses depression and insomnia is ideal. Mar 18, 2024 · Daily dosage may be increased in 50-mg increments every 3 or 4 days based on patient’s response and tolerance. The correct dosage is critical for both safety and effectiveness. It typically comes in tablet form and is taken orally. Jul 1, 2017 · The orexin system regulates the sleep arousal cycle that promotes wakefulness. The 8 pound dog has a 50mg trazadone Rx (100mg tablet, half tablet) and 100mg gabapentin (full tablet) . What if I miss a dose? If you miss a dose of trazodone, take May 1, 2021 · The second-generation antipsychotic drug quetiapine (Seroquel) is increasingly being used off-label for treating insomnia in the general population, possibly to avoid standard medications with known addictive qualities and adverse side effects. Feb 20, 2024 · Starting dose: 150 mg in divided doses daily. Your doctor may start you on a lower dosage of trazodone and titrate the dosage up slowly to minimize the risk of developing side effects. Trazodone for insomnia: A systematic review. So how could this drug help people sleep? Let’s find out. Aug 21, 2024 · For sleep problems, doctors typically prescribe low doses of trazodone, between 25 and 100 milligrams (mg). The typical starting dose for adults with insomnia is 25mg, but this can be increased up to 100 mg as needed. 5 mg each morning. Overview of the treatment of insomnia in adults; Patient education: Insomnia (The Basics) Pharmacotherapy for insomnia in children and adolescents: A rational approach; Poor sleep and insomnia in hospitalized adults; Sleep-wake disturbances and sleep disorders in patients with dementia; Sleep-wake disturbances in shift workers Oct 7, 2022 · For the treatment of depression, a normal starting dose is 150 milligrams (mg) per day. Mirtazapine 15 mg before bedtime. Melatonin + Trazodone 50mg is my new combination now. 5 mg) is marketed for middle-of-the-night use, with the requirement that at least four Jan 15, 2023 · When trazodone is prescribed for use outside of a treatment facility, such as at home, the maximum recommended dose is 400 mg per day. Oct 31, 2023 · insomnia (trouble sleeping) the maximum dosage is 600 mg per day. When I've taken trazodone for insomnia it's been in the range of 25mg - 150mg. The ability to enhance drowsiness may be associated with some risk in elderly patients. Dr gave me trazodone to try for insomnia. Guidelines recommend against trazodone for chronic insomnia based on a short-term trial which evaluated trazodone 50 mg/day and found no clinically significant improvement in sleep outcomes and significantly more side effects (e. But I still didn't wake up feeling fully rested. I started taking trazodone about 3 weeks ago. Trazodone is an antidepressant that’s often used off-label to treat sleep problems. depression Apr 17, 2023 · When prescribing trazodone for sleep, healthcare providers carefully consider the appropriate dosage based on various factors. It can take 1 to 2 weeks before trazodone starts to work, but it may be 4 to 6 weeks before you feel the full benefit. Trazodone interacts with certain medications and alcohol and should be taken only as prescribed. You are correct, they misremembered or I misheard. Trazodone is an oral antidepressant drug. If I start getting close The hypnotic efficacy and daytime effects of trazodone was examined in a double-blind, placebo-controlled crossover study enrolling 16 adult patients with sleep lab–confirmed primary insomnia (sleep efficiency ≤85%). I only felt groggy at higher doses (like 150 mg and above) though. 2 to 81 years; 58. Some clinical trials recommend a starting dosage range from 50 mg to 150 mg per day. Made me happier and stabilized my mood with hardly any side effects. 4-fold, the half-life increased by 2. Oct 14, 2024 · Dose Selection. And also you don't want to ever increase the dose without your doctor. 42 Compared with placebo, suvorexant in doses of 10 and 20 mg decreased first-night sleep latency by an average of 3. Khouzam HR. 3 If you are taking trazodone, make sure to follow the directions that your doctor gives you. While trazodone can be an effective sleep aid, there are important safety concerns to consider with high doses. [ 51 ] Paroxetine 20 mg nocturnally. Dose may increase by 50 mg per day every 3–4 days. Sep 7, 2020 · Insomnia: Studies showed that administering 50 to 100 mg per day of trazodone helped nonorganic insomnia due to depressive disorder, with 100 mg dosage as the most effective to improve sleep. It took about 45 mins to kick in. Maximum dose: 400 mg per day in divided doses . I started with half of the smallest dose and that was doing ok for me. 5 mg. The recommended initial dosage of trazodone is 150 mg/day taken in divided doses. e The dose may be increased by 50 mg/day every 3 to 4 days. At this dosage level, you tend to fall asleep in less than 35 minutes from the time a dose. Taking too high a dose of Trazodone may have the adverse effect of keeping you awake rather than helping you sleep. " Is it safe to take trazodone for insomnia? Although trazodone was designed to treat depression and anxiety disorders, the medication is now widely prescribed as a nighttime sleep aid for patients who suffer from acute insomnia. I was calmer and not so anxious. Your dose may go up or down depending on how it affects you. Dec 15, 2023 · Learn about the typical and maximum trazodone dosages for depression and insomnia, and how to adjust them for older adults and drug interactions. After reading some reviews, I will share what the pharmacist instructed Dec 16, 2024 · Trazodone is a versatile medication frequently prescribed by veterinarians to manage anxiety, stress, and behavioral issues in dogs. The maximum dosage of trazodone for sleep is generally considered to be 300 milligrams per day. 50 mg tablets; 100 mg tablets; and sleep problems. Trazodone comes as tablets, capsules and liquid that you swallow. When used to help with insomnia, this drug is prescribed in low doses - anywhere between 50-150 mg. But if your HCP prescribes trazodone to you off-label for sleep, the dose ranges from 25 to 100 mg by mouth, taken about 30 minutes before bedtime. It has worked so well for my sleep. by 50 mg/day q3-4 days; Max: 400 mg/day if outpatient, 600 mg/day if inpatient; Info: taper dose gradually to D/C insomnia (off-label) [25-50 mg PO qhs] Max: 200 mg/day; Info: often used as adjuvant to SSRI tx; taper dose gradually to D/C if long-term, high-dose use renal dosing [no I LOVE Trazodone. In this article, we will delve into what trazodone is, how it works, its use for sleep, determining the maximum dose, and the potential side effects and risks associated with it. Find out about the side effects, precautions, and frequently asked questions about trazodone. Feb 15, 2024 · The regular tablet form is the most common way to take trazodone for insomnia, but your doctor may prescribe extended-release tablets or capsules depending on your medical history and sleep issues. 001). The maximum recommended dose of 300 mg is not a target to aim for, but rather an upper limit that should only be approached with caution and under close medical supervision. Follow his or her instructions. Child dosage (ages 0–17 years) Your doctor may lower your trazodone dosage if you take drugs that can increase trazodone Aug 16, 2024 · The dose may be increased by 50 mg/day every 3 to 4 days. For mood swings and depressive disorders, maximum dose can reach up to 400 mg within a 24-hour timeline. Adverse effects Apr 17, 2023 · Maximum Dosage of Trazodone for Sleep Understanding the Maximum Dosage. Aug 18, 2024 · The most common doses of Seroquel used in clinical sleep trials ranged from 25 mg to 300 mg once daily before bed. Trazodone 50 mg is a medication commonly prescribed for insomnia‚ a sleep disorder characterized by difficulty falling asleep‚ staying asleep‚ or both. The dose may be adjusted every three to four days with increment of 50 mg/day. 35,36 Given these limitations, current evidence suggests The initial starting dose usually is 150 mg per day, which is increased by 50 mg/day every 3-7 days. Best to get as much sleep as you can especially after it being bad for so long. We will also explore Jul 17, 2024 · Meta-analyses of trazodone trials have shown inconsistent effects on sleep-onset latency, wake after sleep onset, and total sleep time. Factors Influencing the Dosage. "Took 50 mg trazodone for insomnia. What are trazodone tablets? More recently, eight studies were performed with depressed or dysthymic patients, and these studies focused on the effects of trazodone in treating medication-induced or depression-associated insomnia. However, evidence to support using it in this way is scant, and quetiapine is associated with weight gain and other metabolic effects. 3 to 11 times the maximum recommended human dose (MRHD) of 400 mg/day in adults on an mg/m² basis; there was also an increase in congenital anomalies in the rabbit at approximately 7. , headache, daytime somnolence) vs. Seriously after reading reddit and watching youtube videos i’m a bit afraid to even try it. Doctors usually prescribe trazodone when other antidepressants have not worked or have caused side effects. But you should contact your healthcare professional if you experience any bothersome side effects or don’t feel like trazodone is working for you. 75 to 3. The side effects were the worst. Children—Use and dose must be determined by your doctor. Also helped me fall asleep super quickly and sleep through the night. Dose Selection An initial dose of 150 mg/day in divided doses is suggested. Oct 17, 2023 · Read this article to find out more information about trazodone for sleep. Trazodone is a serotonin antagonist and reuptake inhibitor (SARI)‚ meaning it affects the levels of serotonin‚ a neurotransmitter involved in regulating mood‚ sleep‚ and appetite. For depression, the usual dose is 150mg daily. Aug 26, 2024 · Maximum Dosage Considerations. It may take 2 weeks or longer before you feel the full benefit of trazodone. Trazodone Interactions. I found it took me a long time for my body/brain to get into a good sleep pattern again. However, the dose is usually not more than 375 mg per day. My son has been having a lot of trouble sleeping lately even on guanfacine and the dev pediatrician mentioned at 3 we could try trazodone when he’s a little older (he’s 4). She didn’t mention any dangers above that, just that it’s likely a bust and more side effects accumulate above that. Sep 11, 2024 · The tablets should be swallowed whole unless only half a dose is needed and then they should be broken along the scoreline. Apr 17, 2023 · Trazodone is a commonly prescribed medication for sleep disorders, particularly insomnia. I've had over 8 hours sleep for 3 nights in a row. chuck1957 Mar 28, 2024 · Trazodone hydrochloride has been shown to cause increased fetal resorption and other adverse effects on the fetus in the rat when given at dose levels approximately 7. 07 vs. She said try either 50 or 10… Aug 5, 2019 · Because trazodone doesn’t fall under any of these categories, it’s often referred to as an "atypical antidepressant. As a treatment for depression, higher doses of trazodone (150-600 mg) are needed. Your doctor will likely prescribe a low dose, only increasing if necessary. Trazodone prescription and dosage information for physicians and health care professionals. 2% female). It may take several weeks for the full effects of trazodone to be felt, so it is important to continue taking it as directed. Determining the Maximum Dosage of Trazodone for Sleep. Every 3 or 4 days, your prescriber can increase your dose by 50mg, depending on individual response. 100 mg tablets, but scored to break in half or thirds. This clinical case illustrates an acute extrapyramidal event induced by a low dose of trazodone. I haven't had sleep like this in months and months. However, the trazodone max dosage for sleep is generally around 100-150 mg. It's only available on prescription. Oct 1, 2024 · Starting dose: 150 mg in divided doses daily. Trazodone controls depression, but does not cure it. Trazodone is a tetracyclic antidepressant medication. The maximum dose for outpatients usually should not exceed 400 mg/day in divided doses . a reduction of dosage. Your doctor may decrease your dose once your condition is controlled. 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